Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates Academic Article Article uri icon

Overview

MeSH Major

  • Aorta, Thoracic
  • Blood Vessel Prosthesis
  • Blood Vessel Prosthesis Implantation
  • Endovascular Procedures
  • Postoperative Complications
  • Prosthesis Failure
  • Stents

abstract

  • These data show that blocking monocyte adhesion by use of an anti-VLA-4 antibody significantly reduces the number of intimal macrophages, intimal cell proliferation, and intimal hyperplasia in injured carotid arteries in baboons. This study supports a central role for macrophages in the development of intimal hyperplasia and may suggest a new therapeutic strategy to prevent clinical restenosis.

publication date

  • August 12, 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0741-5214(97)70151-4

PubMed ID

  • 9240326

Additional Document Info

start page

  • 87

end page

  • 93

volume

  • 26

number

  • 1