Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Molecular Diagnostic Techniques
  • Molecular Targeted Therapy
  • Neoplasms

abstract

  • These data show that cell-surface peptidases are differentially expressed by normal prostatic stromal and epithelial cells, with increased expression of APA in the stroma surrounding prostate cancer cells, absent APN expression in most tumor cells, and a decreased frequency of DPP IV expression in metastatic tumors. Further studies will elucidate the biological effects of the presence or loss of cell-surface peptidases in the benign and malignant prostate.

publication date

  • December 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0045(19971201)33:4<225::AID-PROS1>3.0.CO;2-G

PubMed ID

  • 9397193

Additional Document Info

start page

  • 225

end page

  • 32

volume

  • 33

number

  • 4