Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells Academic Article uri icon

Overview

MeSH Major

  • Financing, Organized
  • Medical Oncology
  • National Institutes of Health (U.S.)
  • Neoplasms
  • Research Support as Topic
  • Training Support

abstract

  • A library of epothilone A and B analogues, which was constructed by solid-phase combinatorial synthesis using SMART Microreactors and solution chemistry, was screened !n two different tubulin binding assays. Selected compounds were subjected to cytotoxicity studies against a number of cell lines, including Taxol-resistant cells. Important structure-activity relationships emerged from these studies; which sets the stage for further discoveries and developments in the anticancer field.

publication date

  • January 1997

Research

keywords

  • Academic Article

Additional Document Info

start page

  • 2097

end page

  • 2103

volume

  • 36

number

  • 19