Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities Academic Article Article uri icon

Overview

MeSH Major

  • Intubation, Intratracheal
  • One-Lung Ventilation

abstract

  • Serum TNF increases rapidly during lower extremity ischemia and causes increased production of NO from the lung by upregulating iNOS. Increased NO is associated with more severe lung injury, and iNOS blockade has beneficial effects on the lung. TNF blockade before ischemia decreases NO production by the lung and attenuates lung injury. ENO can be used as an early marker of lung injury caused by lower extremity I/R.

publication date

  • November 5, 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0741-5214(97)70065-X

PubMed ID

  • 9357467

Additional Document Info

start page

  • 647

end page

  • 56

volume

  • 26

number

  • 4