Retinal ischemia induced by the intraluminal suture method in rats Academic Article Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Mesothelioma
  • Spinal Neoplasms

abstract

  • In a model of transient focal cerebral ischemia in male Sprague-Dawley rats, which is induced by the intraluminal suture method, the acute effects on the electrical function of the retina were monitored by recording the electroretinogram. The electroretinogram was recorded from halothane-anesthetized rats before, during and after vascular occlusion through the intraluminal suture method for 180 min. During vascular occlusion the amplitude of the a- and b-wave were markedly suppressed. Upon reperfusion the a-wave recovered immediately. During reperfusion up to 48 h the amplitude of the b-wave increased to approximately 50% of the pre-occlusion value did not fully recover. Immunohistochemistry of the retinas revealed that the vascular occlusion induced the expression of glial fibrillary acidic protein in retinal Müller cells. The present data suggest that the intraluminal suture method leads to retinal ischemia.

publication date

  • August 22, 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0304-3940(97)00575-2

PubMed ID

  • 9292888

Additional Document Info

start page

  • 45

end page

  • 8

volume

  • 232

number

  • 1