Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma Academic Article uri icon

Overview

MeSH Major

  • Cell Transformation, Neoplastic
  • Genes, bcl-2
  • Lymphoma, Follicular
  • Lymphoma, Large B-Cell, Diffuse
  • Translocation, Genetic

abstract

  • These findings demonstrate that FL and DLL cells may be clonally related or unrelated. They also show that transformation of FL cells can be associated with somatic point mutations of the bcl-2 oncogene ORF sequence resulting in alteration of the p26-bcl-2a gene product.

publication date

  • July 22, 1997

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9209654

Additional Document Info

start page

  • 119

end page

  • 22

volume

  • 8

number

  • SUPPL. 2