Rapid induction of B-cell lymphomas by avian leukosis virus Academic Article uri icon

Overview

MeSH Major

  • Avian Leukosis Virus
  • Lymphoma, B-Cell

abstract

  • Avian leukosis viruses (ALVs) that induce rapid B-cell lymphomas integrate into the c-myb gene and produce an ALV-myb read-through RNA, which is spliced to produce a truncated Myb protein. The genetic determinants of such recombinant ALVs have been mapped to a 42-nt deletion within the gag gene. This deletion increases splicing efficiency since it is located within a negative regulator of splicing. We propose that the deletion leads to increased production of Myb protein by increasing splicing of an ALV-myb pre-mRNA.

publication date

  • August 7, 1997

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9209336

Additional Document Info

start page

  • 179

end page

  • 82

volume

  • 11

number

  • SUPPL. 3