Early response to therapy and outcome in childhood acute lymphoblastic leukemia: A review Article Report uri icon

Overview

MeSH Major

  • Chromosome Aberrations
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 8
  • Leukemia-Lymphoma, Adult T-Cell
  • Lymphoma, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta
  • Translocation, Genetic

abstract

  • Early response to therapy, whether determined by evaluation of bone marrow or peripheral blood, is a consistent, independent prognostic factor in childhood acute lymphoblastic leukemia. Slower early response may serve as a useful surrogate for outcome, a more complex end point, in investigations of the cellular and molecular determinants of resistance to therapy. It may also allow early identification of a patient subpopulation for whom current therapy is less effective and alternative strategies may be justified.

publication date

  • November 1997

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0142(19971101)80:9<1717::AID-CNCR4>3.0.CO;2-B

PubMed ID

  • 9351539

Additional Document Info

start page

  • 1717

end page

  • 26

volume

  • 80

number

  • 9