Normal human B cell sub-populations and their malignant counterparts Article Report uri icon


MeSH Major

  • Autoimmune Diseases
  • Genes, Immunoglobulin
  • Immunoglobulin Variable Region


  • Seven tonsillar B cell sub-sets have been isolated according to cell surface molecular markers. The molecular characteristics of their phenotype, cell cycle, survival, somatic mutations and isotype switch status permit their inter-relationships to be followed up until the plasma cell stage. Different lymphoma types correlate with all except one of the stages and only two out of nine non-Hodgkin's B cell lymphomas cannot be presently associated to a normal peripheral B cell sub-set. The assignment of lymphomas to their normal human B cell counterparts will facilitate the identification of the causative event(s) responsible for the malignant transformation.

publication date

  • November 26, 1997



  • Report


Digital Object Identifier (DOI)

  • 10.1016/S0950-3536(97)80024-8

PubMed ID

  • 9421614

Additional Document Info

start page

  • 525

end page

  • 38


  • 10


  • 3