Role for the amini-terminal region of human TBP in U6 snRNA transcription Academic Article Article uri icon


MeSH Major

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation, Neoplastic
  • Lung Neoplasms
  • Protein Kinase Inhibitors


  • Basal transcription from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc). TBP consists of a conserved carboxyl-terminal domain that performs all known functions of the protein and a nonconserved amino-terminal region of unknown function. Here, the amino-terminal region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAPc to the U6 promoter, and enhance U6 transcription.

publication date

  • February 21, 1997



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.275.5303.1136

PubMed ID

  • 9027316

Additional Document Info

start page

  • 1136

end page

  • 40


  • 275


  • 5303