IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production Academic Article uri icon


MeSH Major

  • Insulin-Like Growth Factor Binding Protein 1
  • Interleukin-6


  • TNF alpha and IL-1 beta have previously been shown to increase the IGFBP-1 concentration in plasma and liver under in vivo conditions. The present study demonstrates that another inflammatory cytokine, IL-6, also elevates a 30- to 32-kDa IGF binding protein in the plasma of mice. Moreover, IL-6 produced dose- and time-dependent increases in IGFBP-1 production by HepG2 cells. The maximal IL-6-induced increase in IGFBP-1 was comparable to that observed with dexamethasone, and this increase was attenuated by diltiazem or dantrolene, both of which are known to reduce the cytosolic Ca2+ concentration. Finally, incubation of HepG2 cells with TNF alpha or IL-1 beta also increased IGFBP-1 in a dose-dependent manner. These results demonstrate that IGFBP-1 production is mediated directly by proinflammatory cytokines and suggest that this mechanism may be important for the upregulation of IGFBP-1 seen in catabolic conditions associated with overexpression of these cytokines.

publication date

  • November 12, 1996



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1996.1705

PubMed ID

  • 8920958

Additional Document Info

start page

  • 611

end page

  • 5


  • 228


  • 2