Comparative genomic hybridization for genetic analysis of renal oncocytomas Academic Article Article uri icon

Overview

MeSH Major

  • Nomograms
  • Prostate-Specific Antigen
  • Prostatic Neoplasms

abstract

  • Renal oncocytomas are uncommon tumors of the kidney that are considered to be of low malignant potential. Neither conventional cytogenetic nor restriction fragment length polymorphism analyses have identified consistent genetic alterations in their genomic DNA. The purpose of the present study was to identify the genetic alterations associated with the development of renal oncocytomas. We studied 13 renal oncocytomas by using comparative genomic hybridization, and we identified loss of genetic material from chromosomes 1 and/or 14 in six of these tumors. These alterations may represent early genetic events in the development of these tumors.

publication date

  • December 1996

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1098-2264(199612)17:4<199::AID-GCC1>3.0.CO;2-Z

PubMed ID

  • 8946201

Additional Document Info

start page

  • 199

end page

  • 204

volume

  • 17

number

  • 4