Absence of neuronal and glial proteins in human and rat leptomeninges in situ Academic Article Article uri icon

Overview

MeSH Major

  • Ketoglutarate Dehydrogenase Complex
  • Neurodegenerative Diseases
  • Reactive Oxygen Species

abstract

  • Human leptomeningeal (arachnoid and pia mater) cells in culture have been demonstrated in replicated studies to express typical neuronal proteins such as neurofilament protein and neuron-specific enolase. In addition, they can express glial fibrillary acidic protein. The present study examines the possibility that neuronal and glial proteins might be present in rat and human leptomeningeal cells in situ. The neuronal proteins 160 kDa and 200 kDa neurofilaments, neuron-specific enolase and microtubule-associated protein 2 were, however, not immunolocalized in either the pia mater or arachnoid. Glial fibrillary acidic protein and galactocerebroside were also not detected, while fibronectin and vimentin immunoreactivities were robust in all layers of the leptomeninges. Together with the previously reported expression of some neuronal and astroglial markers in cultured human leptomeninges, these observations suggest that culture alters the properties of leptomeningeal cells.

publication date

  • December 1996

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0022-510X(96)00189-X

PubMed ID

  • 8994100

Additional Document Info

start page

  • 21

end page

  • 3

volume

  • 144

number

  • 1-2