Suppression of experimental autoimmune neuritis by phosphodiesterase inhibitor pentoxifylline Academic Article Article uri icon

Overview

MeSH Major

  • Astrocytoma
  • Central Nervous System Neoplasms
  • Isocitrate Dehydrogenase
  • Mutation
  • Neuropil

abstract

  • Phosphodiesterase inhibitor pentoxifylline (POX) has been shown to have multiple immunomodulatory effects in vitro and in vivo. It inhibits T cell proliferation, T helper 1-type cytokines, and tumor necrosis factor. We postulated that POX might have an in vivo immunomodulatory effect on a T-cell-mediated autoimmune peripheral nervous system disease, experimental autoimmune neuritis (EAN). We investigated the effect of POX on EAN in rats immunized with peripheral nerve myelin containing neuritogenic peptide SP26. At 200 mg/kg/day, there was significant suppression of clinical EAN, weight loss, and T cell proliferation to SP26 compared to controls. Proliferation of T cells from immunized rats to SP26 was suppressed by POX in vitro. These studies demonstrate a beneficial role for POX in EAN, with potential applicability to human autoimmune demyelination.

publication date

  • November 1996

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0022-510X(96)00195-5

PubMed ID

  • 8981293

Additional Document Info

start page

  • 14

end page

  • 8

volume

  • 143

number

  • 1-2