Gramicidin channels - A solvable membrane "protein" folding problem Review uri icon

Overview

MeSH Major

  • Gramicidin
  • Ion Channels

abstract

  • The linear gramicidins are peptide antibiotics that form cation-selective channels in lipid bilayers. Gramicidin channels have very well-defined functional characteristics, and the structure of membrane-spanning gramicidin A channels is known at atomic resolution. These features make the gramicidins well suited to study how the amino acid sequence encodes the structure and function of a membrane-spanning channel. We show how one can use electrophysiological measurements to obtain structural information about conducting channels and to quantify the conformational preferences of sequence-substituted gramicidin mutants.

publication date

  • October 1996

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 9029812

Additional Document Info

start page

  • 331

end page

  • 42

volume

  • 33

number

  • 5