Direct in vivo gene transfer to canine myocardium using a replication-deficient adenovirus vector Academic Article uri icon

Overview

MeSH Major

  • Enterocolitis, Necrotizing
  • Infant, Premature
  • Infant, Premature, Diseases

abstract

  • Adenovirus-mediated direct myocardial gene transfer can be accomplished safely in a large animal model, providing high levels of protein expression in a greater spatial distribution than previously reported, with minimal transfection of distant organs. Sustained and localized expression of a potent angiogenic mediator has been accomplished, which may provide an innovative strategy to stimulate angiogenesis in ischemic myocardium.

publication date

  • August 1996

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0003-4975(96)00328-1

Additional Document Info

start page

  • 425

end page

  • 33; discussion 433-4

volume

  • 62

number

  • 2