The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors Article uri icon

Overview

MeSH Major

  • Mesothelioma
  • Pleural Neoplasms

abstract

  • The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-alpha, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.

publication date

  • August 1996

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/1359-6101(96)00016-0

PubMed ID

  • 8899291

Additional Document Info

start page

  • 133

end page

  • 41

volume

  • 7

number

  • 2