Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Jews
  • Neoplasm Proteins
  • Ovarian Neoplasms
  • Sequence Deletion
  • Transcription Factors

abstract

  • The lifetime risk of breast cancer may approach 80-90% in women who have germline mutations of either of two genes, BRCA1 or BRCA2. A single BRCA1 mutation, 185delAG, has been noted in approximately 20% of Ashkenazi Jewish women with early onset breast cancer and in 0.9% of the Ashkenazi population. We recently detected a 6174delT frameshift mutation in BRCA2 in an hereditary breast cancer kindred of Ashkenazi Jewish ancestry. Here, we investigated the frequency of this mutation in 200 women with early-onset breast cancer. Six of 80 Ashkenazi Jewish women (8%) diagnosed with breast cancer before the age of 42, wer heterozygous for the 6174delT mutation, compared to none of 93 non-Jewish women diagnosed with breast cancer at the same age (P = .005). These cases were ascertained without regard to family history. Two of 27 (7%) additional Jewish families in which the proband was diagnosed with breast cancer at age 42 to 50 and had a family history of breast or ovarian cancer had germline 6174delT mutations. The results of this report suggest that a recurrent mutation of BRCA1 and a recurrent mutation BRCA2 together may account for over a quarter of all early-onset breast cancer in the setting of a personal or family history of ovarian cancer in Ashkenazi Jewish women.

publication date

  • May 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8673092

Additional Document Info

start page

  • 126

end page

  • 8

volume

  • 13

number

  • 1