Serum levels of GM-CSF are elevated in patients with thrombocytopenia Academic Article uri icon

Overview

MeSH Major

  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Thrombocytopenia

abstract

  • Serum levels of GM-CSF, IL-3 and IL-6 were measured in patients with immune thrombocytopenia (ITP), non-immune thrombocytopenia (NIT), autoimmune haemolytic anaemia (AIHA) and neutropenia. 8/10 children with ITP had elevated serum levels of GM-CSF (mean 18.4 pg/ml) while thrombocytopenic, but only two had detectable levels (mean 4.5 pg/ml) after normalization of the platelet count. In patients with NIT a significant inverse correlation between platelet count and serum levels of GM-CSF was observed. IL-3 and IL-6 levels were not significantly elevated in thrombocytopenic patients and only two of the nine patients with either AIHA or neutropenia had detectable levels of GM-CSF. Thus, GM-CSF may play a role in the response of severe thrombocytopenia.

publication date

  • February 8, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8603021

Additional Document Info

start page

  • 486

end page

  • 8

volume

  • 92

number

  • 2