Reduced levels of transforming growth factor β receptor type II in human prostate cancer: An immunohistochemical study Academic Article uri icon

Overview

MeSH Major

  • Prostatic Neoplasms
  • Receptors, Transforming Growth Factor beta

abstract

  • In previous studies we demonstrated that the growth of human prostatic adenocarcinoma is associated with aberrant accumulation of transforming growth factor (TGF) beta1, a growth factor that has been shown to be a potent inhibitor of epithelial cell proliferation. We investigated the expression of TGF-beta receptor II (TGFbetaR-II) in benign prostate tissue and in prostate cancer using standard immunohistochemical techniques. Quantitation of immunopositivity for TGFbetaR-II was assessed on a visual analogue scale ranging from 0 (absence of staining) to 4+ (intensely positive staining). All of the benign glandular epithelia stained intensely, either 3+ or 4+, representative of the ubiquitous nature of TGFbetaR-II in normal tissue. Overall, staining was reduced in prostate cancer sections, and there was progressively diminished staining as the histological grade of the cancer increased (P < 0.01, Kruskal-Wallis test). This immunohistochemical study indicates that a decline in the levels of TGFbetaR-II is correlated with advancing histological aggressiveness of the cancer and suggests that aberrant TGFbetaR-II function may play a role in human prostate carcinogenesis.

publication date

  • April 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9816213

Additional Document Info

start page

  • 635

end page

  • 40

volume

  • 2

number

  • 4