Phosphoinositide kinases Article uri icon

Overview

MeSH Major

  • Fatty Acids
  • Neoplasms

abstract

  • Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.

publication date

  • April 1996

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0955-0674(96)80060-3

Additional Document Info

start page

  • 153

end page

  • 8

volume

  • 8

number

  • 2