Phosphoinositides as regulators in membrane traffic Review uri icon

Overview

MeSH Major

  • Cell Membrane
  • Inositol Phosphates
  • Intracellular Membranes
  • Membrane Proteins
  • Phosphatidylinositols

abstract

  • Phosphorylated products of phosphatidylinositol play critical roles in the regulation of membrane traffic, in addition to their classical roles as second messengers in signal transduction at the cell surface. Growing evidence suggests that phosphorylation-dephosphorylation of the polar heads of phosphoinositides (polyphosphorylated inositol lipids) in specific intracellular locations signals either the recruitment or the activation of proteins essential for vesicular transport. Cross talk between phosphatidylinositol metabolites and guanosine triphosphatases is an important feature of these regulatory mechanisms.

publication date

  • March 15, 1996

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 8599109

Additional Document Info

start page

  • 1533

end page

  • 9

volume

  • 271

number

  • 5255