Pentavalent antimony-mannan conjugate therapy of experimental visceral leishmaniasis Academic Article uri icon

Overview

MeSH Major

  • Antimony Sodium Gluconate
  • Antiprotozoal Agents
  • Leishmania donovani
  • Leishmaniasis, Visceral
  • Mannans

abstract

  • Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six-fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.

publication date

  • December 9, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8916804

Additional Document Info

start page

  • 444

end page

  • 6

volume

  • 55

number

  • 4