Regulation of an early developmental checkpoint in the B cell pathway by Igβ Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD
  • B-Lymphocytes
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Recombination, Genetic

abstract

  • Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig)M heavy chain (mu) and the Ig alpha-Ig beta signal transducers. The role of Ig beta in regulating early B cell development was examined in mice that lack Ig beta (Ig beta-/-). These mice had a complete block in B cell development at the immature CD43+B220+ stage. Immunoglobulin heavy chain diversity (DH) and joining (JH) segments rearranged, but variable (VH) to DJH recombination and immunoglobulin messenger RNA expression were compromised. These experiments define an unexpected, early requirement for Ig(beta) to produce B cells that can complete VDJH recombination.

publication date

  • April 19, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.272.5260.411

PubMed ID

  • 8602530

Additional Document Info

start page

  • 411

end page

  • 4

volume

  • 272

number

  • 5260