Diabetic peripheral neuropathy: A clinicopathologic and immunohistochemical analysis of sural nerve biopsies Academic Article Article uri icon


MeSH Major

  • Antibodies, Anti-Idiotypic
  • Gangliosides
  • Immunoglobulin M
  • Myelin-Associated Glycoprotein


  • We performed quantitative immunohistochemical studies of sural nerve biopsy specimens from 20 patients to determine whether endoneurial and epineurial lymphocytic infiltration occurs in diabetic nerves. The diabetic nerves contained a mean of 129 CD3+ cells per tissue section compared to 19 cells in patients with chronic neuropathy matched for the histologic severity of disease, and 0-5 cells in normal control nerves. The T-cell infiltrates in the diabetic nerves were predominantly of the CD8+ cell type. Activated endoneurial lymphocytes expressed immunoreactive cytokines and major histocompatibility class II antigens. Microvasculitis was found in 12 (60%) patients. Infiltrative T cells may contribute to the pathogenesis of diabetic neuropathy through a variety of effector mechanisms.

publication date

  • June 1996



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-4598(199606)19:6<722::AID-MUS6>3.0.CO;2-C

PubMed ID

  • 8609922

Additional Document Info

start page

  • 722

end page

  • 7


  • 19


  • 6