Antiphospholipid antibodies activate vascular endothelial cells Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Antiphospholipid
  • Endothelium, Vascular

abstract

  • Antiphospholipid antibodies (aPL) are associated with a syndrome of arterial and venous thrombosis and recurrent fetal loss. We have shown that IgG purified from patients with aPL activate vascular endothelial cells (EC), converting the steady-state, non-thrombotic endothelial surface to a pro-thrombotic state. The aPL-activated EC are characterized by the expression of leukocyte adhesion molecules, including ICAM-1, VCAM, and E-selectin. EC activation is dependent upon the presence of beta 2-GP-I, a cofactor necessary for anticardiolipin reactivity. In addition, EC activation is not attributable to endotoxin contamination, Fc receptor interactions, or immune complexes, but rather is the result of the specific anticardiolipin reactivity of the IgG. Endothelial activation by aPL may be an important mechanism by which these antibodies cause a hypercoagulable state.

publication date

  • November 2, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8902777

Additional Document Info

start page

  • 440

end page

  • 1

volume

  • 5

number

  • 5