Focal segmental glomerulosclerosis with acute renal failure associated with α-interferon therapy Academic Article uri icon


MeSH Major

  • Acute Kidney Injury
  • Glomerulosclerosis, Focal Segmental
  • Interferon-alpha


  • Both alpha- and beta- interferons (IFNs) have been increasingly used for the treatment of many types of malignancy, and recently the use of alpha-IFN in the management of hepatitis C virus (HCV) infection with or without renal involvement has been emphasized. We report a patient who developed nephrotic syndrome and acute renal failure while being treated with alpha-IFN for HCV infection. The renal biopsy showed focal segmental glomerulosclerosis and tubulointerstitial nephritis. Although several renal lesions have been described in association with either alpha-IFN treatment or HCV infection, focal segmental glomerulosclerosis has not been emphasized in either instance. This case also indicates that when renal abnormalities occur during treatment of HCV infection with alpha-IFN, kidney biopsy may define the responsible renal lesions, suggest possible association with other conditions, and serve as a guideline for proper management.

publication date

  • December 1996



  • Academic Article



  • eng

PubMed ID

  • 8957041

Additional Document Info

start page

  • 888

end page

  • 92


  • 28


  • 6