Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia Academic Article uri icon

Overview

MeSH Major

  • Ischemic Attack, Transient
  • Nitric Oxide Synthase

abstract

  • Transient focal ischemia leads to iNOS expression in postischemic brain. However, the spatial and temporal patterns of expression differ from those occurring in permanent ischemia: iNOS is induced earlier and predominantly in vascular cells rather than in neutrophils. Thus, the temporal profile and localization of postischemic iNOS expression depend on the nature of the ischemic insult. The finding that aminoguanidine reduces infarct size adds further support to the hypothesis that postischemic iNOS expression contributes to ischemic brain damage.

publication date

  • August 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8711805

Additional Document Info

start page

  • 1373

end page

  • 80

volume

  • 27

number

  • 8