Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder. Academic Article uri icon

Overview

MeSH

  • Adult
  • Blood Platelets
  • DNA, Complementary
  • Female
  • Humans
  • Male
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Serotonin Plasma Membrane Transport Proteins

MeSH Major

  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Obsessive-Compulsive Disorder

abstract

  • Epidemiologic studies indicate that obsessive-compulsive disorder is genetically transmitted in some families, although no genetic abnormalities have been identified in individuals with this disorder. The selective response of obsessive-compulsive disorder to treatment with agents which block serotonin reuptake suggests the gene coding for the serotonin transporter as a candidate gene. The primary structure of the serotonin-transporter coding region was sequenced in 22 patients with obsessive-compulsive disorder, using direct PCR sequencing of cDNA synthesized from platelet serotonin-transporter mRNA. No variations in amino-acid sequence were found among the obsessive-compulsive disorder patients or healthy controls. These results do not support a role for alteration in the primary structure of the coding region of the serotonin-transporter gene in the pathogenesis of obsessive-compulsive disorder.

publication date

  • July 26, 1996

has subject area

  • Adult
  • Blood Platelets
  • Carrier Proteins
  • DNA, Complementary
  • Female
  • Humans
  • Male
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Obsessive-Compulsive Disorder
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Serotonin Plasma Membrane Transport Proteins

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1096-8628(19960726)67:4<409::AID-AJMG16>3.0.CO;2-N

PubMed ID

  • 8837711

Additional Document Info

start page

  • 409

end page

  • 411

volume

  • 67

number

  • 4