'Osteoclastic' giant cell carcinoma of the pancreas: Report of a case with aspiration cytology
Comparative Genomic Hybridization
Multinucleate giant cells can be seen in pancreatic abscesses, fat necrosis, pseudocysts, tuberculosis, sarcoidosis and fungal infections. When the cells are associated with malignant epithelial cells, the differential diagnosis includes metastatic carcinoma, malignant melanoma, Hodgkin's disease, large cel anaplastic lymphoma, trophoblastic tumor, epithelioid sarcoma, malignant fibrous histiocytoma, angiosarcoma and rhabdomyosarcoma. Immunohistochemical stains, such as vimentin, S-100, leukocyte common antigen, human chorionic gonadotropin, Factor VII Ag, actin and desmin play an important role in differentiating between these lesions.