Nitric oxide synthesis inhibition and right ventricular systolic function in swine
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Ventricular Function, Right
These data indicate that L-NAME produces constriction of resistance vessels within the lung, leading to increased steady-state RV afterload, but had little direct effect on large pulmonary vessels and pulsatile RV load. RV pump performance declines after L-NAME, but contractility is preserved, indicating that the change in systolic performance results primarily from the increase in steady-state afterload.