Nitric oxide synthesis inhibition and right ventricular systolic function in swine Academic Article uri icon

Overview

MeSH Major

  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Systole
  • Ventricular Function, Right

abstract

  • These data indicate that L-NAME produces constriction of resistance vessels within the lung, leading to increased steady-state RV afterload, but had little direct effect on large pulmonary vessels and pulsatile RV load. RV pump performance declines after L-NAME, but contractility is preserved, indicating that the change in systolic performance results primarily from the increase in steady-state afterload.

publication date

  • December 30, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8969400

Additional Document Info

start page

  • 909

end page

  • 14

volume

  • 10

number

  • 7