Fluid flow inhibits endothelial adhesiveness: Nitric oxide and transcriptional regulation of VCAM-1 Academic Article uri icon

Overview

MeSH Major

  • Blood Circulation
  • Endothelium, Vascular
  • Nitric Oxide
  • Transcription, Genetic
  • Vascular Cell Adhesion Molecule-1

abstract

  • Previous exposure to fluid flow decreased cytokine- or lipoprotein-stimulated endothelial cell superoxide production, VCAM-1 expression, and monocyte binding; the effects of flow appear to be due to NO. Flow-mediated NO-dependent regulation of oxidant-responsive transcription may influence the site of a lesion.

publication date

  • October 4, 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8840861

Additional Document Info

start page

  • 1682

end page

  • 9

volume

  • 94

number

  • 7