Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion Academic Article uri icon

Overview

MeSH Major

  • Arginine
  • Arterial Occlusive Diseases
  • Brain
  • Brain Damage, Chronic
  • Cerebral Arterial Diseases
  • Enzyme Inhibitors
  • Guanidines
  • Ischemic Attack, Transient
  • Nitric Oxide Synthase

abstract

  • These results demonstrate that cerebral ischemia is also associated with iNOS expression in a minimally invasive model of transient MCA occlusion and that iNOS inhibition reduces focal ischemic damage. The findings support the hypothesis that nitric oxide produced by iNOS contributes to ischemic brain damage and that inhibition of iNOS may be a valuable tool in the management of cerebral ischemia.

publication date

  • February 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8571430

Additional Document Info

start page

  • 317

end page

  • 23

volume

  • 27

number

  • 2