Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE) Academic Article uri icon

Overview

MeSH Major

  • Enzymes
  • Gene Expression Regulation, Enzymologic
  • Oxidative Stress
  • Regulatory Sequences, Nucleic Acid

abstract

  • Induction of heme oxygenase-1 is regulated by several chemically distinct classes of inducers (mostly electrophiles), which also induce phase 2 enzymes, and these inductions are mediated by similar AREs. These findings support the importance of HO-1 as a protector against oxidative damage and suggest that HO-1 induction is part of a more generalized protective cellular response that involves phase 2 enzymes.

publication date

  • November 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2230011

PubMed ID

  • 8612205

Additional Document Info

start page

  • 827

end page

  • 37

volume

  • 1

number

  • 7