Basal ganglia phantom simulation: improvement of relative quantitation in SPECT [I-123] dynamic neuroreceptor imaging
Cone-Beam Computed Tomography
Databases as Topic
The [I-123] labeled radiopharmaceuticals are being used to study neuroreceptors in monkey and human brain with a triple headed SPECT system. To optimized the quantitative accuracies of the monkey dynamic neuroreceptor studies, a combination of collimators - high-resolution fan-beam collimators (HRF), ultra HRF (UHRF), a count rate dependent 2-D Wiener (2-DW) prefiltering, 3-D Wiener postfiltering techniques (3-DW) is studied. The acquisition parameters are designed to simulate the dynamic neuroreceptor studies in the monkey. The results indicate that the UHRF with 3-DW improves images quantization in SPECT neuroreceptor imaging.