CDC25 phosphatases as potential human oncogenes Academic Article uri icon

Overview

MeSH Major

  • Cell Cycle Proteins
  • Cell Transformation, Neoplastic
  • Multigene Family
  • Oncogenes
  • Phosphoprotein Phosphatases

abstract

  • Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RASG12V or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.7667636

PubMed ID

  • 7667636

Additional Document Info

start page

  • 1575

end page

  • 7

volume

  • 269

number

  • 5230