Boundary layer infusion of heparin prevents thrombosis and reduces neointimal hyperplasia in venous polytetrafluoroethylene grafts without systemic anticoagulation Academic Article Article uri icon

Overview

MeSH Major

  • Aorta, Thoracic
  • Blood Vessel Prosthesis
  • Blood Vessel Prosthesis Implantation
  • Endovascular Procedures
  • Postoperative Complications
  • Prosthesis Failure
  • Stents

abstract

  • These data demonstrate that the local boundary layer infusion of heparin significantly increases overall inferior vena cava graft patency (p = 0.014) and markedly reduces downstream anastomotic neointimal hyperplasia and cell proliferation. This approach may represent an attractive strategy for antithrombotic therapy in venous replacement with synthetic graft materials.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0741-5214(95)70136-2

PubMed ID

  • 7674466

Additional Document Info

start page

  • 237

end page

  • 45; discussion 246-7

volume

  • 22

number

  • 3