Boundary layer infusion of heparin prevents thrombosis and reduces neointimal hyperplasia in venous polytetrafluoroethylene grafts without systemic anticoagulation
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
These data demonstrate that the local boundary layer infusion of heparin significantly increases overall inferior vena cava graft patency (p = 0.014) and markedly reduces downstream anastomotic neointimal hyperplasia and cell proliferation. This approach may represent an attractive strategy for antithrombotic therapy in venous replacement with synthetic graft materials.