A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. Academic Article uri icon

Overview

MeSH

  • Adult
  • Bronchi
  • Clinical Protocols
  • DNA, Complementary
  • Epithelium
  • Female
  • Genetic Vectors
  • Humans
  • Male
  • Nasal Mucosa
  • Patient Selection
  • Recombinant Proteins
  • Virus Replication

MeSH Major

  • Adenoviridae
  • Clinical Trials, Phase I as Topic
  • Cystic Fibrosis
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Transfer Techniques
  • Genetic Therapy

publication date

  • May 1995

has subject area

  • Adenoviridae
  • Adult
  • Bronchi
  • Clinical Protocols
  • Clinical Trials, Phase I as Topic
  • Cystic Fibrosis
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • DNA, Complementary
  • Epithelium
  • Female
  • Gene Transfer Techniques
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Male
  • Nasal Mucosa
  • Patient Selection
  • Recombinant Proteins
  • Virus Replication

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1089/hum.1995.6.5-643

PubMed ID

  • 7578401

Additional Document Info

start page

  • 643

end page

  • 666

volume

  • 6

number

  • 5