Effect of amlodipine on left ventricular mass in the Amlodipine Cardiovascular Community Trial. Academic Article Article uri icon

Overview

MeSH

  • Adult
  • African Continental Ancestry Group
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Blood Pressure
  • Echocardiography
  • European Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organ Size

MeSH Major

  • Amlodipine
  • Calcium Channel Blockers
  • Heart Ventricles
  • Hypertension
  • Hypertrophy, Left Ventricular

abstract

  • As part of the Amlodipine Cardiovascular Community Trial (ACCT), which was a large multicenter study designed to assess the effects of the calcium channel blocker amlodipine besylate (Norvasc) as monotherapy for treatment of mild to moderate hypertension, we sought to determine the effects of amlodipine on regression of left ventricular (LV) hypertrophy (LVH). The study began with a 2-week placebo run-in period (baseline), before which antihypertensive drugs had been discontinued. Amlodipine was then administered at 5-10 mg/day during a 4-week titration/efficacy period. Patients achieving a goal diastolic blood pressure (DBP) of < or = 90 mm Hg or a decrease in DBP of > or = 10 mm Hg entered a 12-week maintenance phase and had the option to continue long-term therapy thereafter. Echocardiograms were obtained in a subset of patients at the end of the baseline period. In patients with LVH at baseline, echocardiograms were repeated at the end of 16 weeks of therapy (week 18), and at 42 weeks in patients continuing long-term therapy. Thirty-seven percent of 124 hypertensive patients screened for LVH at baseline had LVH detected on echocardiograms. Blacks had a higher incidence of LVH (64%) as compared with whites (34%, p < 0.05). Patients with LVH were more likely to have a higher baseline systolic BP (SBP) and DBP. Their sitting SBP and DBP decreased significantly from a mean of 163/102 mm Hg at baseline to 139/86 mm Hg with amlodipine therapy at week 18 (p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

authors

publication date

  • September 1995

has subject area

  • Adult
  • African Continental Ancestry Group
  • Aged
  • Aged, 80 and over
  • Amlodipine
  • Analysis of Variance
  • Blood Pressure
  • Calcium Channel Blockers
  • Echocardiography
  • European Continental Ancestry Group
  • Female
  • Heart Ventricles
  • Humans
  • Hypertension
  • Hypertrophy, Left Ventricular
  • Male
  • Middle Aged
  • Organ Size

Research

keywords

  • Clinical Trial
  • Journal Article
  • Multicenter Study

Identity

Language

  • eng

PubMed ID

  • 8583790

Additional Document Info

start page

  • 471

end page

  • 476

volume

  • 26

number

  • 3