Telomerase activity in normal and malignant hematopoietic cells Academic Article Article uri icon

Overview

MeSH Major

  • Dendritic Cells
  • Graft vs Host Disease
  • Immunotherapy, Adoptive

abstract

  • Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a PCR-based assay. Telomerase was also detectable in nonmalignant bone marrow and peripheral blood leukocytes from normal donors, including fractions enriched for granulocytes, T lymphocytes, and monocytes/B cells. Semiquantitative comparison revealed considerable overlap between telomerase activities in samples from normal subjects and leukemia patients, confounding evaluation of the role of telomerase in this disease. These data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres.

publication date

  • September 26, 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.92.20.9082

PubMed ID

  • 7568077

Additional Document Info

start page

  • 9082

end page

  • 6

volume

  • 92

number

  • 20