Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin Academic Article uri icon

Overview

MeSH Major

  • Isotretinoin
  • Mouth Neoplasms
  • Precancerous Conditions
  • Receptors, Retinoic Acid

abstract

  • The expression of retinoic acid receptor-beta mRNA is selectively lost in premalignant oral lesions and can be restored by treatment with isotretinoin. Restoration of the expression of retinoic acid receptor-beta mRNA is associated with a clinical response. Retinoic acid receptor-beta may have a role in mediating the response to retinoids and may be a useful intermediate biologic marker in trials of these agents for the prevention of oral carcinogenesis.

publication date

  • May 25, 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM199505253322103

PubMed ID

  • 7723796

Additional Document Info

start page

  • 1405

end page

  • 10

volume

  • 332

number

  • 21