Does endotoxin stimulate cells by mimicking ceramide? Academic Article Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Sphingolipids

abstract

  • Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0167-5699(95)80185-5

PubMed ID

  • 7544978

Additional Document Info

start page

  • 297

end page

  • 302

volume

  • 16

number

  • 6