Lack of interferon γ receptor β chain and the prevention of interferon γ signaling in TH1 Cells Academic Article uri icon

Overview

MeSH Major

  • Interferon-gamma
  • Proto-Oncogene Proteins
  • Receptors, Interferon
  • Signal Transduction
  • Th1 Cells
  • Th2 Cells

abstract

  • The ability of interferon gamma (IFN-gamma) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that helper cell subsets might differ in their activation of the IFN-gamma signaling pathway. The IFN-gamma-inducible signal transducing factor (STF-IFN gamma) was activated in murine TH2 but not in TH1 cell clones, because in the latter the second chain of the IFN-gamma receptor (accessory factor 1 or IFN-gamma R beta) was absent. Thus, TH1 cells use receptor modification to prevent the activation of STF-IFN gamma and achieve an IFN-gamma-resistant state.

publication date

  • December 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7618088

Additional Document Info

start page

  • 245

end page

  • 7

volume

  • 269

number

  • 5221