Interaction of a peptidomimetic aminimide inhibitor with elastase Academic Article uri icon

Overview

MeSH Major

  • Anilides
  • Dipeptides
  • Hydrazines
  • Pancreatic Elastase

abstract

  • The crystal structure of an aminimide analog of a dipeptide inhibitor of porcine pancreatic elastase bound to its target serine protease has been solved. The peptidomimetic molecule binds in the same fashion as the class of dipeptides from which it was derived, making similar interactions with the subsites on the elastase surface. Because aminimides are readily synthesized from a wide variety of starting materials, they form the basis for a combinatorial chemistry approach to rational drug design.

publication date

  • January 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7604279

Additional Document Info

start page

  • 66

end page

  • 9

volume

  • 269

number

  • 5220