Sr2+ can become incorporated into an agonist-sensitive, cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium Academic Article Article uri icon

Overview

MeSH Major

  • Esophagus
  • Fluorodeoxyglucose F18
  • Lipoma
  • Liposarcoma
  • Polyps
  • Positron-Emission Tomography
  • Tomography, X-Ray Computed

abstract

  • We have explored the properties of a Ca(2+)-dependent cell-signalling pathway that becomes active when cultured equine sweat gland cells are stimulated with ATP. The ATP-regulated, Ca(2+)-influx pathway allowed Sr2+ to enter the cytoplasm but permitted only a minimal influx of Ba2+. Experiments in which cells were repeatedly stimulated with ATP suggested that Sr2+, but not Ba2+, could become incorporated into the agonist-sensitive, cytoplasmic Ca2+ store. Further evidence for this was provided by experiments using ionomycin, a Ca2+ ionophore which has no affinity for Sr2+.

publication date

  • August 1995

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1007/BF01922434

PubMed ID

  • 7649240

Additional Document Info

start page

  • 804

end page

  • 8

volume

  • 51

number

  • 8