all‐trans retinoic acid for treating germ cell tumors. In vitro activity and results of a phase II trial
Fallopian Tube Neoplasms
Tomography, X-Ray Computed
A Phase II clinical trial of RA failed to show significant clinical antitumor activity in patients with chemotherapy-refractory GCTs. However in vitro data suggest that the control of growth and maturation in some GCT cell lines involve the RA signaling pathway. Further studies are warranted to define the role that other retinoids with receptor selectivity or more favorable pharmacologic properties may play in the maturation or antitumor responses of GCTs.