Transforming growth factor-β1: Comparative immunohistochemical localization in human primary and metastatic prostate cancer Academic Article uri icon


MeSH Major

  • Adenocarcinoma
  • Carcinoma
  • Prostatic Neoplasms
  • Transforming Growth Factor beta


  • These findings confirm our previous observation that prostate cancer exhibits enhanced intracellular and extracellular accumulation of TGF-beta 1 relative to normal prostate tissue and benign prostatic hyperplasia. In addition, our study documented a significantly more pronounced accumulation of intracellular TGF-beta 1 in primary prostate cancer with metastasis than in primary tumors without metastasis. Moreover, although the pattern of intracellular TGF-beta 1 staining observed in the primary tumor is maintained in the metastasis, a lack of extracellular accumulation of TGF-beta 1 in the metastatic site was noted. This differential pattern may be biologically important and could conceivably reflect a role for TGF-beta 1 in disease progression.

publication date

  • January 1995



  • Academic Article



  • eng

PubMed ID

  • 7474936

Additional Document Info

start page

  • 628

end page

  • 35


  • 73


  • 5