Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women. Academic Article Article uri icon

Overview

MeSH

  • Adrenocorticotropic Hormone
  • Adult
  • Animals
  • Blood Glucose
  • Epinephrine
  • Estradiol
  • Female
  • Humans
  • Hydrocortisone
  • Norepinephrine
  • Oxytocin
  • Prolactin
  • Rats
  • Time Factors
  • Vasopressins

MeSH Major

  • Exercise Test
  • Hormones
  • Hypothalamo-Hypophyseal System
  • Lactation
  • Pituitary-Adrenal System
  • Postpartum Period
  • Stress, Physiological

abstract

  • In the rat, lactation suppresses a variety of physiological responses to stress. We investigated whether stress-responsive neurohormonal systems are also restrained during breast feeding in humans. We chose treadmill exercise as a stressor because this stimulus produces an exercise intensity-dependent activation of the hypothalamic-pituitary-adrenal axis and the sympathomedullary system that is independent of differences in physical conditioning among subjects. Ten lactating and ten nonlactating women who were between 7 and 18 weeks postpartum performed 20 min of graded treadmill exercise. The final 5 min of exercise was set to elicit 90% of the maximal oxygen uptake of each subject. Plasma ACTH, cortisol, and glucose responses to exercise were significantly attenuated in lactating women (P < 0.001, P < 0.05, and P < 0.001, respectively). Basal norepinephrine levels were also reduced in lactating women (P < 0.05). These results indicate that stress-responsive neurohormonal systems are restrained in lactating women.

publication date

  • October 1995

has subject area

  • Adrenocorticotropic Hormone
  • Adult
  • Animals
  • Blood Glucose
  • Epinephrine
  • Estradiol
  • Exercise Test
  • Female
  • Hormones
  • Humans
  • Hydrocortisone
  • Hypothalamo-Hypophyseal System
  • Lactation
  • Norepinephrine
  • Oxytocin
  • Pituitary-Adrenal System
  • Postpartum Period
  • Prolactin
  • Rats
  • Stress, Physiological
  • Time Factors
  • Vasopressins

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1210/jcem.80.10.7559880

PubMed ID

  • 7559880

Additional Document Info

start page

  • 2954

end page

  • 2959

volume

  • 80

number

  • 10