Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Genes, p53
  • Head and Neck Neoplasms
  • Mutation
  • Smoking

abstract

  • In our study, a history of tobacco and alcohol use was associated with a high frequency of p53 mutations in patients with squamous-cell carcinoma of the head and neck. Preliminary evidence linked cigarette smoking to p53 mutations at nonendogenous mutation sites. Our findings suggest a role for tobacco in the molecular progression of squamous-cell carcinoma of the head and neck and support the epidemiologic evidence that abstinence from smoking is important to prevent head and neck cancer.

publication date

  • March 16, 1995

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM199503163321104

PubMed ID

  • 7854378

Additional Document Info

start page

  • 712

end page

  • 7

volume

  • 332

number

  • 11