Immunohistochemical detection of HER2/neu in patients with axillary lymph node negative breast carcinoma. A study of epidemiologic risk factors, histologic features, and prognosis Academic Article Article uri icon


MeSH Major

  • Algorithms
  • Fetal Growth Retardation
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Infant, Small for Gestational Age
  • Ultrasonography, Prenatal


  • The results obtained in this study suggest that the immunohistochemical demonstration of HER is not a reliable prognostic indicator for patients with axillary lymph node negative breast carcinoma. This marker was not associated with major epidemiologic risk factors; however, there was a significant correlation between HER and the phenotypic features of breast carcinoma because medullary carcinoma is rarely HER(+). Although the associations may not be a strong enough basis for refining the classification of breast carcinoma, they could be useful for diagnosing individual patients. The changes in HER that are detectable by the immunohistochemical methods used in this study probably do not occur in the earliest stages of mammary carcinogenesis.

publication date

  • January 1995



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19950315)75:6<1320::AID-CNCR2820750614>3.0.CO;2-C

PubMed ID

  • 7882282

Additional Document Info

start page

  • 1320

end page

  • 6


  • 75


  • 6